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The CDKN2A cyclin-dependent kinase inhibitor 2A gene at 9p21 is a tumour suppressor gene that has been shown to be deleted in wide range of human malignancies. Loss of the CDKN2A gene results in cellular proliferation and dysregulation of pro-apoptotic pathways. Losses of the CDKN2A region have also been reported in malignant mesothelioma, melanoma, and bladder cancer 8,9, Accept Decline.
Applications haematology. Request a quote. Probe Specification P16, 9p Probe Information The CDKN2A cyclin-dependent kinase inhibitor 2A gene at 9p21 is a tumour suppressor gene that has been shown to be deleted in wide range of human malignancies.
Not only do Cytocell offer an extensive range of high-quality FISH probes, the customer support is also excellent — providing fast access to all the probes I need. The probes are highly consistent with bright signals allowing easy scoring of results.
References Møller MB, et al. Section E9 of the American College of Medical Genetics technical standards and guidelines: fluorescence in situ hybridization. Genet Med. Preclinical validation of fluorescence in situ hybridization assays for clinical practice. Genetics in Medicine. Microscope Images. Hazard Label Information Sheet.